Pfizer Canada has announced the first recipients of the Pfizer Cardiovascular Research Awards program. The program, launched in October 2005, has been developed to fund and support cardiovascular research in Canada. The six recipients are: Dr. Benot Drolet, Assistant Professor at the Faculty of Pharmacy, Laval University and Laval Hospital Research Center; Dr. Julie St-Pierre, Research Associate, Faculty of Pharmacy at Laval Hospital Research Center and a medical resident in pediatrics at the Mother-Child Hospital Center of Laval University; Dr. Alain Rivard, Associate Professor of Medicine at University of Montreal and Notre-Dame Hospital, Cardiology Division; Dr. Denis de Blois, Associate Professor, Department of Pharmacology and University Drug Discovery Group, University of Montreal; Dr. Jacques Genest, Professor of Medicine at McGill University and Royal Victoria Hospital, Cardiology Division; and Dr. Stewart Charles Whitman, Assistant Professor, University of Ottawa Heart Institute, Pathology and Laboratory Medicine. The Pfizer Cardiovascular Research Awards program is designed to support a variety of initiatives, from traditional clinical trials, to smaller projects in Canadian research. All proposals were reviewed by an independent committee of 12 Canadian cardiovascular experts, chaired by Dr. Jean-Claude Tardif, Director, Research Center, Montreal Heart Institute, Professor of Medicine, Universit de Montral and recipient of the Pfizer-Canadian Institutes of Health Research Chair of Atherosclerosis.
References: 1. Duvic, M., K. Hymes, et al. 2001 ; . "Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results." Journal of Clinical Oncology 19 9 ; : 2456-71. 2. Duvic, M., A. G. Martin, et al. 2001 ; . "Phase 2 and 3 clinical trial of oral bexarotene Targretin capsules ; for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma." Archives of Dermatology 137 5 ; : 581-93.
Dhandapani, K. M., and D. W. Brann. 2002. Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 67: 1379-85.
409-422. J. B., Rich, K. A. and de Kretser, D. M. 1979b ; . Effects of experimental cryptorchidism on the ultrastructure and function of the Sertoli cell and peritubular tissue of the rat testis. Biol. Reprod. 21, 823-838. Kramer, C. V. 1956 ; . Extension of multiple range tests to group means with unequal numbers of replications. Biometrics 12, 307-310. Lee, V.W.K., de Kretser, D. M., Hudson, B. H. and Wang, C. 1975 ; . Variations in serum FSH, LH.
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In March 2007, the Company announced changes to the board of directors including naming John L. Higgins, Todd C. Davis, Elizabeth M. Greetham and David M. Knott as directors; and the resignation of directors John Groom, Irving S. Johnson, Ph.D., Daniel Loeb, Carl C. Peck, M.D. and Brigette Roberts, M.D. Additionally, director John W. Kozarich was named chairman of the board, replacing Henry F. Blissenbach, who remains a director. In February 2007, Ligand completed the sale of AVINZA morphine sulfate extended release capsules ; and associated assets to King Pharmaceuticals, Inc. in exchange for cash and royalties. Ligand received 0.4 million in cash, which represents the purchase price of 6.3 million, net of certain inventory adjustments of .7 million and less .0 million placed into escrow, plus .1 million in reimbursement of payments previously made to Organon and others. In January 2007, Ligand announced a restructuring including the elimination of approximately 204 positions across all functional areas. Associated with the restructuring, several executive officers agreed to step down including the Company's Chief Financial Officer, Chief Scientific Officer and General Counsel. In January 2007, John L. Higgins joined the Company as Chief Executive Officer, President and in March 2007 was named a member of its board of directors. In November 2006, Ligand announced initiation of clinical trials for LGD-4665, an oral, small-molecule drug that mimics the activity of thrombopoietin TPO ; , a growth factor that promotes growth and production of blood platelets. In November 2006, noteholders of Ligand's outstanding 6% convertible subordinated notes, in the aggregate principal amount of 8.2 million, converted all of the notes into 20.8 million shares of common stock. Accrued interest and unamortized debt issue costs related to the converted notes of ##TEXT##.2 million and .0 million, respectively, were recorded as additional paid-in capital. Ligand currently has approximately 101.0 million shares outstanding. In October 2006, Ligand completed the sale of its oncology product line to Eisai Co., Ltd. Tokyo ; and Eisai Inc. New Jersey ; for 5.0 million. Of this, 5.0 million was received in cash and .0 million was placed into escrow. The sale included Ligand's four marketed oncology drugs ONTAK denileukin diftitox ; , Targretin bexarotene ; capsules, Targretin bexarotene ; gel 1% and Panretin alitretinoin ; gel 0.1.
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Muscarinic receptor ligand 5R, 6R ; 6 - 3-propylthio1, 2, 5-thiadiazol-4-yl ; -1-azabicyclo[3.2.1]octane. European Journal of Pharmacology, 356, 109 119. Pharmacology 356.
HE16 concentration in other relevant CNS tissues Figure 5 ; . In hamsters treated correlated with the hE16 levels in CNS tissues and CSF at 7 dpi. Data from the WNV-infected and sham-infected hamsters were combined, because there were no statistical differences in the hE16 tissue concentrations between the groups data not shown ; . There was a generally linear trend between increased serum and tissue levels of hE16, as the R2 values between serum and CSF, cerebral cortex, brain stem, and thoracic lumbar spinal cord were 0.47, 0.45, 0.57 and 0.17, respectively. Thus, with the exception of the thoracic lumbar spinal cord, serum concentrations of hE16 were indicators of other neurological tissue concentrations and taxotere.
Presented in part at the American Gastroenterological Association Digestive Disease Week in San Francisco, May 1922, 2002, and in Orlando, Fla., May 1722, 2003, and at the United European Gastroenterology Week in Geneva, October 1923, 2002. Supported by Centocor. Dr. Sands was supported in part by a grant K23 DK002850 ; from the National Institutes of Health. Dr. Sands reports having served as a paid consultant on advisory boards to Centocor, Elan Biogen, Protein Design Labs, Celltech, Otsuka America Pharmaceutical, and Berlex and having received lecture fees from Centocor and AstraZeneca and grant support from Centocor, Abbott, and Elan. Dr. Anderson reports having received consulting fees from Bristol-Myers Squibb, HoffmannLaRoche, Agouron, and Axcan Pharma and lecture fees from Schering Canada, HoffmannLaRoche, and Glaxo-Welcome. Dr. Bernstein reports having received consulting fees from Elan, Abbott, and Novartis Canada, owning stock in Pfizer, and having received grant support from Ferring Canada. Dr. Feagan reports having received consulting and lecture fees from Centocor and Schering-Plough. Dr. Fedorak reports having received consulting fees from Abbott, Celltech, and Serono and grant support from Centocor, Abbott, Serono, Millennium Pharmaceuticals, and Wyeth. Dr. Korzenik reports having received consulting fees from Amgen, Isis Pharmaceuticals, Berlex, and Incara, lecture fees from Centocor, Procter & Gamble, and Berlex, and grant support from Rhodia. Dr. Lashner reports having received lecture fees from AstraZeneca, Procter & Gamble, and Prometheus Laboratories. Dr. Onken reports owning stock in Schering-Plough. Dr. Rutgeerts reports having received consulting and lecture fees from Centocor, Schering-Plough, Celltech, Serono, and Elan Biogen and grant support from Centocor and ScheringPlough. Dr. Wild reports having received consulting and lecture fees from Schering Canada. Dr. Wolf reports having received consulting fees from Centocor, AstraZeneca, Janssen, and Otsuka America Pharmaceutical. Dr. van Deventer reports having received consulting fees from Centocor, Schering-Plough, Merix Bioscience, Elan, Biogen, and Serono, owning stock in Merix Biosciences and Amsterdam Molecular Therapeutics, having received lecture fees from Centocor, Schering-Plough, AstraZeneca, and Elan, and having received grant support from Centocor, Protein Design Labs, Serono, and Genzyme. Mr. Marsters, Dr. Travers, and Dr. Blank are employees of Centocor and own Johnson & Johnson stock options.
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Figure 1. Channel currents recorded from cultured spinal neurons. Currents are recorded on a digital oscilloscope at 1-set sweeps with a sampling rate of 1024 set-`. A, Channels activated by muscimol. Muscimol records typically show a mixture of short and long jumps as summarized in Table I. The longest event shown in this figure fourth trace from top ; is over 400 msec long. B, GABA-induced current jumps and tazorac.
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4. Jung, D., A. Rozek, M. Okon, and R. E. Hancock. 2004. Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem. Biol. 11: 949-957. 5. Mangili, A., I. Bica, D. R. Snydman, and D. H. Hamer. 2005. Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia. Clin. Infect. Dis. 40: 1058-1060. 6. Marty, F. M., W. W. Yeh, C. B. Wennersten, L. Venkataraman, E. Albano, E. P. Alyea, H. S. Gold, L. R. Baden, and S. K. Pillai. 2006. Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. J. Clin. Microbiol. 44: 595-597. 7. Nishi, H., H. Komatsuzawa, T. Fujiwara, N. McCallum, and M. Sugai. 2004. Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to.
Neose is a biopharmaceutical company focused on the improvement of protein therapeutics through the application of its proprietary technologies. Neose is using its GlycoAdvanceTM, GlycoPEGylationTM and GlycoConjugationTM technologies to develop proprietary protein therapeutics that are designed to be improved versions of currently marketed drugs with proven efficacy. These next generation proteins are expected to offer significant advantages, including less frequent dosing and improved safety and efficacy. In addition to developing its own products or co-developing products with others, Neose is entering into strategic partnerships for the inclusion of its technologies into product design and the manufacturing processes being developed by biotech and pharmaceutical companies. While protein drug development is Neose's primary focus, the breadth and depth of the Company's technologies offer multiple opportunities to participate in the large and rapidly growing therapeutic protein market. Neose is using its technologies to address other challenges in protein drug development, such as manufacturing efficiency and the use of alternate expression systems. The Company is developing additional applications of its technologies that are expected to sustain future growth and telithromycin.
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Continued ; Phyto-oestrogens are predominantly isoflavonoid derivatives found in food plants and are used as dietary supplements to provide similar benefits to HRT, especially in countering some of the side-effects of the menopause in women. These compounds are discussed under isoflavonoids see page 156 ; . Dioscorea wild yam ; root or extract see page 239 ; is also marketed to treat the symptoms of menopause as an alternative to HRT. Although there is a belief that this increases levels of progesterone, which is then used as a biosynthetic precursor of other hormones, there is no evidence that diosgenin is metabolized in the human body to progesterone.
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