Quite bizarre and did not conform to monocytes or their precursors.'6 Rather, monocytes tural dented small present features nuclei cytoplasmic in the described of with by Freeman monocytic dispersed granules, described leukemia. chromatin, and by and.
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Hill Negotiating Insurance Bill Details By Dana Milbank Washington Post Staff Writer Thursday, April 25, 2002; Page A01 President Bush is close to agreement on legislation forcing employers to expand insurance coverage for psychiatric illnesses, a position urged by mental health advocates but one that has been opposed by business groups and several key Republicans. Bush plans to give the idea a strong endorsement Monday, when he is scheduled to speak in Albuquerque at a job training facility for people recovering from mental illnesses, congressional officials said. Those familiar with the status of negotiations, which continued yesterday, cautioned that there may not be agreement by Monday on all details of the legislation, known as "mental health parity." But they said Bush supports the idea and is likely to sign legislation this year. An announcement of expanded mental health coverage in the home state of Sen. Pete V. Domenici RN.M. ; would be a triumph for the lawmaker, who has a child suffering from schizophrenia and who has championed the cause for years. In a broad sense, it would require employers' health insurance plans to treat mental illness the same as other illnesses for the purposes of reimbursements and caps on payouts. "Talks have been going on, " Domenici spokesman Chris Gallegos confirmed. "At this point there is no agreement." A weaker version of the mental parity legislation expired last fall, and Congress has been debating plans to renew and strengthen the law. Supporters said White House backing would likely provide a sufficient push to get the proposal enacted. Moreover, they added, a gesture of support for the mentally ill by the Republican president could reduce the stigma and shame of mental disorders and could boost his "compassionate conservative" credentials. The main opposition has come from key GOP lawmakers in the House, who object to the higher cost the requirement would impose on employers. The White House would need to persuade House conservatives to endorse the idea, which has long had strong backing from Democrats. As wife of the vice president, Tipper Gore made it her signature issue, and Senate Majority Leader Thomas A. Daschle D-S.D. ; has said he hopes to have a vote on the legislation soon. Efforts by the White House to involve itself in mental health parity legislation could head off an election-year battle with Democrats on the subject. Last week, Daschle said he would proceed with the legislation even in the absence of an agreement with the White House. "Mental health parity, I think, is something that's going to pass, " he said.
Public Citizen plays key role in passage of new auto and truck safety law requiring air bags and head injury protections, and limiting the expansion of big rigs. Public Citizen publishes They Love To Fly . And It Shows, exposing House members who took nearly 4, 000 privately funded trips in 1989-90.
12 genzyme corporation genz ; condensed consolidated balance sheets unaudited, amounts in thousands ; june 30, december 31, 2007 2006 cash and all marketable securities $ 1, 500, 148 $ 1, 285, 604 other current assets 1, 504, 093 property, plant and equipment, net 1, 742, 651 intangibles, net 2, 717, 921 other assets 192, 490 126, total assets $ 7, 657, 303 $ 7, 191, 188 current liabilities $ 645, 798 $ 651, 439 noncurrent liabilities 866, 068 879, stockholders equity 6, 145, 437 total liabilities and stockholders equity $ 7, 657, 303 $ 7, 191, 188 genzyme corporation genz ; analyst schedule unaudited, amounts in thousands, except percentage amounts ; q2-07 vs q2-06 ytd q2-06 q3-06 q4-06 q1-07 q2-07 % b w ; fy 2005 fy 2006 6 30 total revenues: renal renagel phosphate binder including sevelamer ; $ 126, 599 $ 134, 722 $ 135, 143 $ 137, 384 $ 144, 954 14 % $ 417, 485 $ 515, 119 $ 282, 338 hectorol 22, 412 25, % 34, 515 93, other renal 31 ; 100 % total renal product and service revenue 148, 980 160, % 452, 000 608, 479 337, renal r& d revenue total renal 148, 980 160, % 452, 000 608, 479 337, therapeutics cerezyme enzyme 253, 989 252, % 932, 322 1, fabrazyme enzyme 89, 041 93, % 305, 064 359, thyrogen hormone 23, 723 22, % 77, 740 93, myozyme enzyme 6, 531 20, % 3, 827 59, other therapeutics 78 72 183 % 2, 292 410 total therapeutics product and service revenue 373, 362 388, % 1, 321, 245 therapeutics r& d revenue 68 638 431 total therapeutics 373, 362 388, % 1, 322, 034 transplant thymoglobulin lymphoglobuline 39, 812 37, % 127, 739 149, other transplant 1, 400 1, % 18, 143 6, total transplant product and service revenue 41, 212 39, % 145, 882 155, transplant r& d revenue 180 30 180 total transplant 41, 212 39, % 145, 912 155, biosurgery synvisc viscosupplementation product and services 63, 590 55, % 218, 908 233, sepra products 21, 961 21, % 68, 171 85, other biosurgery 16, 849 16, ; % 65, 953 67, total biosurgery product and service revenue 102, 400 93, % 353, 032 386, biosurgery r& d revenue 1 888 1, 748 % 144 893 2, total biosurgery 102, 401 93, % 353, 176 387, genetics genetic testing 61, 041 61, % 222, 328 240, total genetics product and service revenue 61, 041 61, % 222, 328 240, genetics r& d revenue total genetics 61, 041 61, % 222, 328 240, other other product and service revenue 62, 752 62, % 220, 195 257, total other product and service revenue 62, 752 62, % 220, 195 257, other r& d revenue 3, 608 3, % 19, 197 15, total other 66, 360 66, % 239, 392 273, total revenues $ 793, 356 $ 808, 574 $ 854, 241 $ 883, 183 $ 933, 419 18 % $ 2, 734, 842 $ 3, 187, 013 $ 1, 816, 602 genzyme corporation genz ; analyst schedule unaudited, amounts in thousands, except percentage and per share amounts ; q2-07 vs q2-06 ytd q2-06 q3-06 q4-06 q1-07 q2-07 % b w ; fy 2005 fy 2006 6 30 revenues: total product and service revenue $ 789, 747 $ 805, 384 $ 848, 239 $ 874, 071 $ 927, 957 18 % $ 2, 714, 682 $ 3, 169, 527 $ 1, 802, 028 total r& d revenue 3, 609 3, % 20, 160 17, total revenues 793, 356 808, % 2, 734, 842 total product and service gross profit 1 ; 604, 414 620, % 2, 082, 030 sg& a expense 1 ; 273, 480 239, ; % 787, 839 1, r& d expense 1, 2 ; 168, 941 162, ; % 502, 657 649, amortization of intangibles 52, 883 50, % 181, 632 209, purchase of in-process research and development 3 ; 552, 900 29, 200 552, charge for impaired goodwill 4 ; 219, 245 219, 245 operating income loss ; 112, 719 47, ; 383, 554 ; 195, 562 181, % 600, 862 190, ; 377, 493 other income expenses ; : equity in income of equity method investments 3, 854 4, % 151 15, 705 minority interest 2, 750 2, ; % 11, 952 10, gain loss ; on investments in equity securities 5 ; 66, 967 128 ; 12, 788 143 ; % 5, 698 73, other 319 ; 873 ; 714 ; 525 ; 278 ; 13 % 1, 535 ; 2, 045 ; 803 ; investment income 12, 563 16, % 31, 429 56, interest expense 4, 035 ; 3, 772 ; 3, 233 ; 4, 188 ; 3, 621 ; 10 % 19, 638 ; 15, 478 ; 7, 809 ; income loss ; before income taxes 1 ; 194, 499 28, ; 364, 956 ; 229, 380 201, % 628, 919 52, ; 430, 761 provision for ; benefit from income taxes 1 ; 60, 002 ; 44, 530 96, ; 61, 432 ; 2 ; % 187, 430 ; 35, 881 132, ; net income loss ; 1 ; $ 134, 497 $ 15, 966 $ 268, 234 ; $ 158, 187 $ 139, 949 4 % $ 441, 489 $ 16, 797 ; $ 298, 136 net income loss ; per share-diluted 1, 6, 7 ; $ 49 $ 06 $ 02 ; $ weighted average shares outstanding-diluted 1, 6, 7 ; 276, 312 278, % 272, 224 261, genzyme corporation genz ; analyst schedule unaudited, amounts in thousands, except percentage amounts ; ytd q2-06 q3-06 q4-06 q1-07 q2-07 fy 2005 fy 2006 6 30 total product and service revenue $ 789, 747 $ 805, 384 $ 848, 239 $ 874, 071 $ 927, 957 $ 2, 714, 682 $ 3, 169, 527 $ 1, 802, 028 as a % of total product and service revenue: renagel phosphate binder including sevelamer ; 16 % 17 % 16 % hectorol 3 % 3 % 3 % cerezyme enzyme 32 % 31 % 31 % fabrazyme enzyme 11 % 11 % 11 % thyrogen hormone 3 % 3 % 3 % myozyme enzyme 1 % 3 % 3 % thymoglobulin lymphoglobuline 5 % 5 % 5 % synvisc viscosupplementation product and services 8 % 7 % 7 % sepra products 3 % 3 % 3 % genetics testing 8 % 8 % 7 % other 10 % 10 % 11 % 100 % 100 % 100 % 100 % 100 % 100 % 100 % 100 % total product and service gross margin 77 % 77 % 77 % total revenues $ 793, 356 $ 808, 574 $ 854, 241 $ 883, 183 $ 933, 419 $ 2, 734, 842 $ 3, 187, 013 $ 1, 816, 602 sg& a expense as a % of total revenue 34 % 30 % 31 % r& d expense as a % of total revenue 21 % 20 % 19 % operating income loss ; as a % of total revenue 14 % 6 ; % 45 ; % benefit from income taxes as a % of profit loss ; before tax 31 % 156 % 27 % 31 % 31 % condensed consolidated balance sheet information: 6 30 06 cash and all marketable securities $ 1, 358, 240 $ 1, 675, 599 $ 1, 285, 604 $ 1, 450, 125 $ 1, 500, 148 $ 1, 089, 102 $ 1, 285, 604 $ 1, 500, 148 other current assets 1, 392, 290 property, plant and equipment, net 1, 458, 222 intangibles, net 4 ; 3, 028, 777 other assets 135, 342 142, total assets $ 7, 372, 871 $ 7, 425, 038 $ 7, 191, 188 $ 7, 474, 665 $ 7, 657, 303 $ 6, 878, 865 $ 7, 191, 188 $ 7, 657, 303 current liabilities $ 616, 632 $ 552, 091 $ 651, 439 $ 661, 321 $ 645, 798 $ 550, 023 $ 651, 439 $ 645, 798 noncurrent liabilities 1, 111, 591 stockholders equity 5, 644, 648 total liabilities and stockholders equity $ 7, 372, 871 $ 7, 425, 038 $ 7, 191, 188 $ 7, 474, 665 $ 7, 657, 303 $ 6, 878, 865 $ 7, 191, 188 $ 7, 657, 303 notes: 1 ; reflects the adoption of financial accounting standards board, or fasb, statement of financial accounting standards no, or fas, 123r, share-based payment, an amendment of fasb statement nos.
Provide evidence of reasoned advice including the preparation and production of reports based on appropriate environmental audits.
NSAIDs are the most common analgesic medication used to treat low back pain. It is most beneficial where inflammatory processes are evident. It works by inhibiting prostaglandin synthesis, primarily through the cyclooxygenase pathway, which occurs in response to injury of the cell membrane. Two broad categories of NSAIDs exist: traditional NSAIDs, which inhibit cyclooxygenase-1 COX-1 ; and cyclooxygenase-2 COX-2 ; , and selective COX-2. COX-2 inhibitors are reported not to interfere with protective prostaglandins in the gastric mucosa and should be used for patients who have a history of or risk factors for peptic ulcerative disease. Oral and sirolimus.
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Carden - F610486 severe headaches, as well as nausea caused by the headaches. Dr. Cavanaugh prescribed Maxalt for migraine headaches, as well as pain medication and Phenergan for nausea. During his testimony, the claimant repeatedly stated that the prescription Maxalt was the only effective medication for controlling his migraine headaches. Dr. Cavanaugh subsequently referred the claimant to Dr. Joseph Chacko, a board certified opthalmologist in Little Rock, Arkansas, with a subspecialty as a neuro-opthalmologist. Dr. Chacko began treating the claimant on September 20, 2006. He has continued to treat the claimant since that time. The claimant has seen a number of physicians since being evaluated by Dr. Chacko, all of which have released the claimant to return to work. In fact, Dr. Chacko is the only physician that has not given the claimant's a full release to return to work without restrictions. As will be set out further below, it appears that the only reason Dr. Chacko has not released the claimant is because of the claimant's own insistence that he cannot work because of continued symptoms. At the hearing the claimant described his continued symptoms as depression, anxiety, nightmares, flashbacks, severe headaches, nausea, nervous twitches, and poor eyesight. Respondents paid temporary total disability through January 5, 2007. The claimant has not worked since that time, apparently relying on the lack of a full release by Dr. Chacko Tr. 22 ; . The claimant's testimony simply lacks credibility. On direct examination, claimant denied ever having any vision problems. However, on cross-examination, -10 and skelaxin.
We have analysed the effects of sevelamer at baseline and after 1, 3 and 6 months on the following data and parameters: calcium, phosphate, intact pth, venous bicarbonate, urea, creatinine, creatinine clearance, side-effects, number of patients that were discontinued, and co-treatment during the study period with phosphate-based binders, calcitriol, lipid-lowering drugs and sodium bicarbonate.
Sir, We thank Jean-Pierre Wauters and colleagues for their helpful comments. The lower level of cyclosporin A CsA ; under sevelamer may indeed be due to a direct binding of CsA by sevelamer, rather than to an indirect impact of sevelamer on bile acids. Thus, the recommendation of a delay between the intake of sevelamer and that of drugs such as CsA is fully warranted. We disagree, however, on the claim that calcium-based binding is fully specific for phosphate. Indeed, the co-administration of either calcium acetate or sevelamer with ciprofloxacin recently has been shown to reduce the oral bioavailability of the latter drug by some 50% [1] and solifenacin.
Darlington Requisition for Controlled Drugs Please supply me with 15 ampoules of diamorphine 5 mg 75 mg ; for the care of patients treated by members of The Medical Centre. Please invoice us in the usual way. Yours sincerely!
Information Theory and Its Application to Health Problems. Roy R. Kuebler, Jr., Ph.D and somatropin.
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Figure 9. Morphologic alteration in injured PTC endothelial cells and lumina 6 wk A through D ; and 8 wk E and F ; after induction of disease. A ; An endothelial cell and basement membrane are partially disrupted arrow ; . Apoptotic bodies that have been ingested by a mononuclear cell in the lumen are seen in the lumen asterisk ; . Magnification, 4000. B ; An endothelial cell asterisk ; is activated and swollen, and its fenestration cannot be recognized. Magnification, 6000. C and D ; Typical apoptotic endothelial cells characterized by condensation of nuclear chromatin C, asterisk ; and crescentic condensed nucleus and nuclear fragments D, asterisk ; . Magnification, 7000. E ; Basement membrane of PTC is partially destroyed arrow ; and an endothelial cell is desquamated asterisk ; . Magnification, 3000. F ; Interstitium is widened and filled with infiltrating cells and fibrotic material. PTC lumina can rarely be identified. Magnification, 1000.
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1. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003; 23: 168175. Lerman A, Burnett JC Jr. Intact and altered endothelium in regulation of vasomotion. Circulation 1992; 86 suppl III ; : III-12III-19. 3. Herrmann J, Lerman LO, Rodriguez-Porcel M, Holmes DR Jr, Richardson DM, Ritman EL, Lerman A. Coronary vasa vasorum neovacularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia. Cardiovasc Res 2001; 51: 762766. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003; 9: 702712. Gulati R, Jevremovic D, Peterson TE, Witt TA, Kleppe LS, Mueske CS, Lerman A, Vile RG, Simari RD. Autologous culture-modified mononuclear cells confer vascular protection after arterial injury. Circulation 2003; 108: 15201526. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk [see comment]. N Engl J Med 2003; 348593600. 7. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, TechnauIhling K, Zeiher AM, Dimmeler S. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 13701376. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, Levine JP, Gurtner GC. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002; 106: 27812786. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, Rutten H, Fichtlscherer S, Martin H, Zeiher AM. HMG-CoA reductase inhibitors statins ; increase endothelial progenitor cells via the PI 3-kinase Akt pathway. J Clin Invest 2001; 108: 391397. Assmus B, Urbich C, Aicher A, Hofmann WK, Haendeler J, Rossig L, Spyridopoulos I, Zeiher AM, Dimmeler S. HMGCoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res 2003; 92: 10491055. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Coll Cardiol 2003; 42: 11491160. Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation 2003; 108: 20492053. Targonski PV, Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Lerman A. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation 2003; 107: 28052809. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 18991906. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000; 101: 948954. Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease [see comment]. Circulation 2003; 108: 20542059. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies, I. Circulation 2003; 108: 16641672. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies, II. Circulation 2003; 108: 17721778. Myerburg RJ, Interian A Jr, Mitrani RM, Kessler KM, Castellanos A. Frequency of sudden cardiac death and profiles of risk. J Cardiol 1997; 80: 10F19F. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105: 11351143. Napoli C, de Nigris F, Palinski W. Multiple role of reactive oxygen species in the arterial wall. J Cell Biochem 2001; 82: 674682. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 10661071. Bogaty P, Hackett D, Davies G, Maseri A. Vasoreactivity of the culprit lesion in unstable angina [see comment]. Circulation 1994; 90: 511. Zeiher AM, Goebel H, Schachinger V, Ihling C. Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque: a clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina. Circulation 1995; 91: 941947. Kinlay S, Behrendt D, Wainstein M, Beltrame J, Fang JC, Creager MA, Selwyn AP, Ganz P. Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation 2001; 104: 11141118. Luscher TF, Barton M. Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation 2000; 102: 24342440 and sorafenib.
By Bob Burnett Americans rank lack of trust in their government as the number four problem facing the United States. Specific reasons include: "Congress not doing anything" 9 percent ; , "Government has wrong priorities" 8 percent ; , "[President] Bush is doing a poor job" 8 percent ; , "Corruption scandals in government lack of ethics" 5 percent ; , and "Political leaders not working together bickering too partisan" 3 percent ; . Over the past twelve months, the trust issue has gradually gained importance and now outranks immigration, education, and global climate change, among others. Two-thirds of Americans say they are "dissatisfied with the way America is being governed"--the highest dissatisfaction rating in 34 years. However, there's a striking.
| Sevelamer dosageWagner, A., and Poindexter, C. A.: Esterification of Serum Cholesterol. I. Serial Determinations in and soriatane.
In Keep It Seasonal, acclaimed chef Annie Wayte shows cooks that ingredients that are truly fresh, local, and in season are better tasting and better for you. Think of a fresh, crisp fall apple, a tender spring artichoke, or a juicy summer peach. They're at their peak in flavor and nutrition, and are a lot more affordable than the trucked-in, out-of-season variety. Annie introduces a world of local butchers, bakers, greengrocers, and farmers who are producing fresh, flavorful food. And that kind of quality is always in season and sevelamer.
4. Pasqualini, R., S. Bourdoulous, E. Koivunen, V. J. Woods, and E. Ruoslahti. 1996. A polymeric form of fibronectin has antimetastatic effects against multiple tumor types. Nat. Med. 2: 1197. 5. Tellier, M. C., G. Greco, M. Klotman, A. Mosoian, A. Cara, W. Arap, E. Ruoslahti, R. Pasqualini, and L. M. Schnapp. 2000. Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4 T lymphocytes. J. Immunol. 164: 3236. 6. He, J., and N. R. Landau. 1995. Use of a novel human immunodeficiency virus type 1 reporter virus expressing human placental alkaline phosphatase to detect an alternative viral receptor. J. Virol. 69: 4587. 7. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, et al. 1996. Identification of a major coreceptor for primary isolates of HIV-1. Nature 381: 661. 8. Naldini, L., U. Blomer, P. Gallay, D. Ory, R. Mulligan, F. H. Gage, I. M. Verma, and D. Trono. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263. 9. Horga, M. A., G. L. Gusella, O. Greengard, N. Poltoratskaia, M. Porotto, and A. Moscona. 2000. Mechanism of interference mediated by human parainfluenza virus type 3 infection. J. Virol. 74: 11792. 10. Hill, C. M., H. Deng, D. Unutmaz, V. N. Kewalramani, L. Bastiani, M. K. Gorny, S. Zolla-Pazner, and D. R. Littman. 1997. Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor. J. Virol. 71: 6296. 11. Zufferey, R., D. Nagy, R. J. Mandel, L. Naldini, and D. Trono. 1997. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol. 15: 871. 12. Cara, A., F. Guarnaccia, M. S. Reitz, R. C. Gallo, and F. Lori. 1995. Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes. Virology 208: 242. 13. Zhong, C., W. M. Chrzanowska, J. Brown, A. Shaub, A. M. Belkin, and K. Burridge. 1998. Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J. Cell Biol. 141: 539. 14. Trkola, A., C. Gordon, J. Matthews, E. Maxwell, T. Ketas, L. Czaplewski, A. E. Proudfoot, and J. P. Moore. 1999. The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivity. J. Virol. 73: 6370. 15. Saphire, A. C., M. D. Bobardt, and P. A. Gallay. 1999. Host cyclophilin A mediates HIV-1 attachment to target cells via heparans. EMBO J. 18: 6771. 16. Moore, J. P. 1997. Coreceptors: implications for HIV pathogenesis and therapy. Science 276: 51. 17. Dardalhon, V., N. Noraz, K. Pollok, C. Rebouissou, M. Boyer, A. Q. Bakker, H. Spits, and N. Taylor. 1999. Green fluorescent protein as a selectable marker of fibronectin- facilitated retroviral gene transfer in primary human T lymphocytes. Hum. Gene Ther. 10: 5. 18. Fehse, B., U. M. Schade, Z. Li, A. Uhde, S. Koch, B. Goller, R. Ruger, N. Fehse, M. Stockschlader, and A. R. Zander. 1998. Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin. Br. J. Haematol. 102: 566. 19. Endres, M. J., P. R. Clapham, M. Marsh, M. Ahuja, J. D. Turner, A. McKnight, J. F. Thomas, B. Stoebenau-Haggarty, S. Choe, P. J. Vance, et al. 1996. CD4independent infection by HIV-2 is mediated by fusin CXCR4. Cell 87: 745. 20. Hoffman, T. L., C. C. LaBranche, W. Zhang, G. Canziani, J. Robinson, I. Chaiken, J. A. Hoxie, and R. W. Doms. 1999. Stable exposure of the corecep and sparfloxacin.
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